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Vaccination is one of the most effective ways to prevent microbial infection. Synthetic vaccines can combine a portion of a microbe, known as an 'antigen' together with an adjuvant that stimulates the immune system. Delivering both the adjuvant and antigen to the appropriate immune cells is challenging. DNA nanotechnology may provide a solution by acting as a scaffold to co-deliver both antigen and adjuvant. However, the potential of DNA nanostructure-based vaccines has only been demonstrated in vitro. Now, a team of researchers based out of Arizona State University demonstrated that DNA nanostructures with appended adjuvants could elicit antibody production against a model antigen in mice.